Mortalin (HSPA9) facilitates BRAF -mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability-Reference-Cited by-同舟云学术

Mortalin (HSPA9) facilitates BRAF -mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability

Published:2020-03-10 Issue:622 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Wu Pui-Kei¹^ORCID,Hong Seung-Keun¹,Chen Wenjing¹,Becker Andrew E.¹,Gundry Rebekah L.¹²^ORCID,Lin Chien-Wei³,Shao Hao⁴^ORCID,Gestwicki Jason E.⁴,Park Jong-In¹^ORCID

Affiliation:

1. Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

2. Center for Biomedical Mass Spectrometry Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

3. Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

4. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Blocking the heat shock chaperone mortalin kills BRAF-mutant and MEK-ERK pathway–driven tumor cells.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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