HES1 Is a Master Regulator of Glucocorticoid Receptor–Dependent Gene Expression-Reference-Cited by-同舟云学术

HES1 Is a Master Regulator of Glucocorticoid Receptor–Dependent Gene Expression

Published:2013-12-03 Issue:304 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Revollo Javier R.¹²,Oakley Robert H.¹,Lu Nick Z.¹³,Kadmiel Mahita¹,Gandhavadi Maheer¹,Cidlowski John A.¹

Affiliation:

1. Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

2. Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

3. Division of Allergy/Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Abstract

A transcription factor that regulates developmental events also suppresses transcriptional responses to stress in adult organisms.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference30 articles.

1. Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements.

2. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

3. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

4. Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.

5. Signalling downstream of activated mammalian Notch

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