Type IV collagen is an activating ligand for the adhesion G protein–coupled receptor GPR126-Reference-Cited by-同舟云学术

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Type IV collagen is an activating ligand for the adhesion G protein–coupled receptor GPR126

Published:2014-08-12 Issue:338 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Paavola Kevin J.¹,Sidik Harwin¹,Zuchero J. Bradley²,Eckart Michael³,Talbot William S.¹

Affiliation:

1. Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Protein and Nucleic Acid Facility, Stanford University School of Medicine, Stanford, CA 94035, USA.

Abstract

Type IV collagen activates the cell surface receptor GPR126, an orphan receptor that is crucial for Schwann cell differentiation and myelination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference67 articles.

1. Seven-transmembrane receptors

2. Receptors and G proteins as primary components of transmembrane signal transduction

3. G Protein-coupled Receptors

4. The Many Faces of G Protein Signaling

5. How many drug targets are there?

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