Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange-Reference-Cited by-同舟云学术

Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange

Published:2018-05-29 Issue:532 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Papasergi-Scott Makaía M.¹^ORCID,Stoveken Hannah M.²,MacConnachie Lauren²^ORCID,Chan Pui-Yee¹^ORCID,Gabay Meital¹,Wong Dorothy²^ORCID,Freeman Robert S.¹^ORCID,Beg Asim A.²,Tall Gregory G.²^ORCID

Affiliation:

1. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.

2. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Abstract

Phosphorylation of evolutionarily conserved sites enhances the function of the Gα subunit chaperone and regulator Ric-8A.

Funder

National Institute of General Medical Sciences

National Institute of Neurological Disorders and Stroke

Muscular Dystrophy Association

PhRMA Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference93 articles.

1. G proteins

2. The Many Faces of G Protein Signaling

3. Seven transmembrane receptors: something old, something new

4. G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

5. Assembly and Trafficking of Heterotrimeric G Proteins

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1. The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A;eLife;2023-11-29

2. The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons;PLOS Genetics;2023-11-01

3. The G protein alpha Chaperone and Guanine-Nucleotide Exchange Factor RIC-8 Regulates Cilia Morphogenesis inCaenorhabditis elegansSensory Neurons;2023-08-26

4. Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms;Structure;2023-05

5. The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A;2022-12-10