An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain

Author:

Qiu Shuang1234,Chen Tao2,Koga Kohei2,Guo Yan-yan15,Xu Hui16,Song Qian1,Wang Jie-jie4,Descalzi Giannina2,Kaang Bong-Kiun3,Luo Jian-hong4,Zhuo Min123,Zhao Ming-gao15

Affiliation:

1. Center for Neuron and Disease, Frontier Institutes of Life Science and of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China.

2. Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada.

3. Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.

4. Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University School of Medicine, Hangzhou 310058, China.

5. Department of Pharmacology, Fourth Military Medical University, Xi’an 710032, China.

6. Institute of Neuroscience, Fourth Military Medical University, Xi’an 710032, China.

Abstract

Inhibiting NMDA receptor function in the insular cortex may prevent the development of neuropathic pain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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