An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease-Reference-Cited by-同舟云学术

An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease

Published:2020-08-04 Issue:643 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Brubaker Douglas K.¹²³^ORCID,Kumar Manu P.¹,Chiswick Evan L.¹^ORCID,Gregg Cecil¹,Starchenko Alina¹^ORCID,Vega Paige N.⁴⁵^ORCID,Southard-Smith Austin N.⁴⁵^ORCID,Simmons Alan J.⁴⁵^ORCID,Scoville Elizabeth A.⁶⁷,Coburn Lori A.⁶⁷⁸^ORCID,Wilson Keith T.⁶⁷⁸⁹,Lau Ken S.⁴⁵⁷^ORCID,Lauffenburger Douglas A.¹^ORCID

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47906, USA.

3. Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, IN 47906, USA.

4. Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

5. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.

6. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

7. Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

8. Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA.

9. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

A platform for comparing trans-omics datasets between IBD mouse models and human patients reveals therapeutically relevant targets.

Funder

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases

Army Research Office

Leona M. and Harry B. Helmsley Charitable Trust

Boehringer Ingelheim

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

2. Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease

3. Optimizing anti-TNF treatments in inflammatory bowel disease

4. Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

5. Molecular Patterns in Human Ulcerative Colitis and Correlation with Response to Infliximab

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