PKC-θ Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation-Reference-Cited by-同舟云学术

PKC-θ Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation

Published:2009-06-23 Issue:76 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gruber Thomas¹,Hermann-Kleiter Natascha¹,Hinterleitner Reinhard¹,Fresser Friedrich¹,Schneider Rainer²,Gastl Günther³,Penninger Josef M.⁴,Baier Gottfried¹

Affiliation:

1. Department of Medical Genetics, Clinical and Molecular Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

2. Institute of Biochemistry, University of Innsbruck, 6020 Innsbruck, Austria.

3. Laboratory of Tumor Immunology, Department of Hematology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

4. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.

Abstract

PKC-θ triggers the degradation of Cbl-b that is necessary for a full immune response in T cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference39 articles.

1. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2. Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

3. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

4. Cbl-b regulates the CD28 dependence of T-cell activation

5. Control of Virus-Specific CD8 + T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection

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