Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation-Reference-Cited by-同舟云学术

Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation

Published:2021-01-19 Issue:666 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Trendel Nicola¹^ORCID,Kruger Philipp¹,Gaglione Stephanie¹^ORCID,Nguyen John¹^ORCID,Pettmann Johannes¹²,Sontag Eduardo D.³^ORCID,Dushek Omer¹^ORCID

Affiliation:

1. Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.

2. Radcliffe Department of Medicine, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX1 3RE Oxford, UK.

3. Electrical and Computer Engineering and Bioengineering, Northeastern University, Boston, MA 02115, USA.

Abstract

Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.

Funder

Wellcome

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference86 articles.

1. T Cell Activation

2. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

3. T Cell Anergy

4. Cell Biology of T Cell Receptor Expression and Regulation

5. Perfect and Near-Perfect Adaptation in Cell Signaling

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