Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1-Reference-Cited by-同舟云学术

Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1

Published:2021-05-04 Issue:681 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

D’Andrea Laura¹,Lucato Christina M.¹,Marquez Elsa A.¹,Chang Yong-Gang¹,Civciristov Srgjan²,Mastos Chantel²,Lupton Christopher J.¹,Huang Cheng¹³,Elmlund Hans¹,Schittenhelm Ralf B.¹³,Mitchell Christina A.¹,Whisstock James C.¹⁴,Halls Michelle L.²,Ellisdon Andrew M.¹

Affiliation:

1. Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.

2. Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 Victoria, Australia.

3. Monash Proteomics & Metabolomics Facility, Monash University, Clayton, 3800 Victoria, Australia.

4. ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, 3800 Victoria, Australia.

Abstract

Mutations that dysregulate a protein complex may promote cancer metastasis by enhancing Rac1 activation.

Funder

Bonneville Power Administration

National Health and Medical Research Council

Skretting Aquaculture Research Centre

Alzheimer Nadační Fond

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

1. The role of PTEN signaling perturbations in cancer and in targeted therapy

2. The functions and regulation of the PTEN tumour suppressor: new modes and prospects

3. Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

4. PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion

5. Structural Mechanisms of PTEN Regulation

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