Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1-Reference-Cited by-同舟云学术

Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

Published:2016-05-31 Issue:430 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Bullen John W.¹²,Tchernyshyov Irina³,Holewinski Ronald J.³,DeVine Lauren⁴,Wu Fan³,Venkatraman Vidya³,Kass David L.³,Cole Robert N.⁴,Van Eyk Jennifer³,Semenza Gregg L.¹²³⁴⁵

Affiliation:

1. Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Activation of PKA in cancer cells or cardiomyocytes results in the increased expression of HIF-1 target genes.

Funder

Public Health Service

National Research Service

National Heart, Lung, and Blood Institute

C. Michael Armstrong Professor at the Johns Hopkins University School of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference39 articles.

1. Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

2. A pathway and network review on beta-adrenoceptor signaling and beta blockers in cardiac remodeling

3. Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

4. β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy

5. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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