Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function-Reference-Cited by-同舟云学术

Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function

Published:2018-08-21 Issue:544 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Salter Alexander I.¹²^ORCID,Ivey Richard G.²,Kennedy Jacob J.²,Voillet Valentin³,Rajan Anusha¹²^ORCID,Alderman Eva J.¹²,Voytovich Uliana J.²^ORCID,Lin Chenwei²,Sommermeyer Daniel¹²,Liu Lingfeng¹²,Whiteaker Jeffrey R.²^ORCID,Gottardo Raphael³^ORCID,Paulovich Amanda G.²,Riddell Stanley R.¹²⁴^ORCID

Affiliation:

1. Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

2. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

Abstract

How potently CAR T cells with CD28 or 4-1BB costimulatory domains stimulate intracellular signaling correlates with treatment efficacy.

Funder

National Cancer Institute

Fred Hutchinson Cancer Research Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference68 articles.

1. Therapeutic T cell engineering

2. Engineering CAR-T cells: Design concepts

3. T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

4. Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

5. Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

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