High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn 2+ -mediated mitochondrial fission-Reference-Cited by-同舟云学术

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn 2+ -mediated mitochondrial fission

Author:

Abuarab Nada¹²³^ORCID,Munsey Tim S.¹^ORCID,Jiang Lin-Hua¹,Li Jing²⁴,Sivaprasadarao Asipu¹²^ORCID

Affiliation:

1. School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, LS2 9JT Leeds, UK.

2. Multidisciplinary Cardiovascular Research Centre, Faculty of Medicine and Health, University of Leeds, LS2 9JT Leeds, UK.

3. College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 9515, Jeddah 21423, Saudi Arabia.

4. School of Medicine, Faculty of Medicine and Health, University of Leeds, LS2 9JT Leeds, UK.

Abstract

ROS produced in response to high glucose trigger mitochondrial fragmentation through a TRPM2-mediated pathway.

Funder

British Heart Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference49 articles.

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