Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling

Author:

Liu Xiangyang1ORCID,Wang Ye1ORCID,Liu Feng1,Zhang Min1,Song Hejie1,Zhou Bin2ORCID,Lo Cecilia W.3ORCID,Tong Shilu4,Hu Zhenlei5ORCID,Zhang Zhen1ORCID

Affiliation:

1. Shanghai Pediatric Congenital Heart Disease Institute and Pediatric Translational Medicine Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

2. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

3. Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA.

4. Department of Clinical Epidemiology and Biostatistics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

5. Department of Cardiovascular Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Abstract

Coronary artery remodeling during development requires the activity of Wdpcp in the epicardial cell layer.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Shanghai Municipal Commission of Health and Family Planning

Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support

Shanghai Institutions of Higher Learning

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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