Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma-Reference-Cited by-同舟云学术

Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma

Published:2020-11-24 Issue:659 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Wang Sheng¹²³^ORCID,Xie Yan²,Huo Yan-Wu¹,Li Yan⁴,Abel Peter W.²,Jiang Haihong²,Zou Xiaohan⁴,Jiao Hai-Zhan¹³,Kuang Xiaolin¹³,Wolff Dennis W.⁵^ORCID,Huang You-Guo¹,Casale Thomas B.⁶^ORCID,Panettieri Reynold A.⁷^ORCID,Wei Taotao¹^ORCID,Cao Zhengyu⁴^ORCID,Tu Yaping²^ORCID

Affiliation:

1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

2. Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.

3. University of Chinese Academy of Sciences, Beijing 100049, China.

4. State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing 211198, China.

5. Kansas City University of Medicine and Biosciences-Joplin, Joplin, MO 64804, USA.

6. Department of Internal Medicine, University of South Florida School of Medicine, Tampa, FL 33612, USA.

7. Rutgers Institute for Translational Medicine and Science, Rutgers Biomedical and Health Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

Abstract

A compound derived from a traditional Chinese medicine targets a phosphodiesterase to induce airway relaxation.

Funder

Foundation for the National Institutes of Health

National Natural Science Foundation of China

the National Key R&D Program of China

the National Laboratory of Biomacromolecules and the Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

Nebrska State

Chinese Academy of Sciences (CAS)/SAFEA International Partnership Program for Creative Research Teams

Publisher

American Association for the Advancement of Science (AAAS)

Subject