Redox-dependent internalization of the purinergic P2Y <sub>6</sub> receptor limits colitis progression-Reference-Cited by-同舟云学术

Redox-dependent internalization of the purinergic P2Y ₆ receptor limits colitis progression

Published:2022-01-11 Issue:716 Volume:15 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Nishiyama Kazuhiro¹^ORCID,Nishimura Akiyuki²³^ORCID,Shimoda Kakeru²³⁴^ORCID,Tanaka Tomohiro²³⁵^ORCID,Kato Yuri¹^ORCID,Shibata Takahiro⁶^ORCID,Tanaka Hiroshi⁷^ORCID,Kurose Hitoshi¹^ORCID,Azuma Yasu-Taka⁸^ORCID,Ihara Hideshi⁹^ORCID,Kumagai Yoshito¹⁰^ORCID,Akaike Takaaki¹¹^ORCID,Eaton Philip¹²,Uchida Koji¹³,Nishida Motohiro¹²³⁴⁵^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

2. National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.

3. Exploratory Research Center on Life and Living Systems (ExCELLS), NINS, Okazaki 444-8787, Japan.

4. Department of Physiological Sciences, SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.

5. Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.

6. Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan.

7. Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1-H-101, Ookayama, Meguro, Tokyo 152-8552, Japan.

8. Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Osaka 598-8531, Japan.

9. Department of Biological Sciences, Graduate School of Science, Osaka Prefecture University, Osaka 599-8531, Japan.

10. Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.

11. Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.

12. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

13. Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan.

Abstract

Cysteine modification of the purinergic receptor P2Y 6 R promotes internalization and degradation and limits colitis progression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference62 articles.

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3. The structure and function of G-protein-coupled receptors

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5. Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270

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