G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β 2 -adrenergic receptor-Reference-Cited by-同舟云学术

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G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β 2 -adrenergic receptor

Published:2018-08-21 Issue:544 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Choi Minjung¹^ORCID,Staus Dean P.²³,Wingler Laura M.²³,Ahn Seungkirl²,Pani Biswaranjan²^ORCID,Capel William D.²,Lefkowitz Robert J.¹²³^ORCID

Affiliation:

1. Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

2. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

3. Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

A mutant GPCR exhibits G protein–biased signaling because of defective phosphorylation by GRK, not because of an inability to bind to β-arrestin.

Funder

National Institutes of Health

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference46 articles.

1. Seven-transmembrane receptors

2. The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

3. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

4. Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

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