Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity

Author:

Nemani Neeharika12ORCID,Dong Zhiwei12,Daw Cassidy C.3ORCID,Madaris Travis R.3ORCID,Ramachandran Karthik3ORCID,Enslow Benjamin T.3ORCID,Rubannelsonkumar Cherubina S.3ORCID,Shanmughapriya Santhanam124ORCID,Mallireddigari Varshini12ORCID,Maity Soumya3,SinghMalla Pragya3,Natarajanseenivasan Kalimuthusamy125,Hooper Robert6,Shannon Christopher E.7ORCID,Tourtellotte Warren G.8,Singh Brij B.9ORCID,Reeves W. Brian3ORCID,Sharma Kumar3ORCID,Norton Luke7ORCID,Srikantan Subramanya3ORCID,Soboloff Jonathan16ORCID,Madesh Muniswamy123ORCID

Affiliation:

1. Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

2. Center for Translational Medicine, Lewis Katz School of Me.dicine at Temple University, Philadelphia, PA, 19140, USA.

3. Department of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.

4. Heart and Vascular Institute, Department of Medicine and Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17601, USA.

5. Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

6. Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA.

7. Department of Medicine/Diabetes Division, University of Texas Health San Antonio, San Antonio, TX 78229, USA.

8. Pathology & Laboratory Medicine, Neurology, Neurosurgery, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

9. Department of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.

Abstract

Nutrient stress triggers transcriptional changes that limit Ca 2+ influx into mitochondria through the MCU.

Funder

NIH Office of the Director

DOD/DHP

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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