Deregulated Ca 2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin-Reference-Cited by-同舟云学术

Deregulated Ca 2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

Published:2017-06-02 Issue:6 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Hu Li-Yen R.¹,Ackermann Maegen A.¹,Hecker Peter A.²,Prosser Benjamin L.³⁴^ORCID,King Brendan¹,O’Connell Kelly A.²,Grogan Alyssa¹,Meyer Logan C.⁵^ORCID,Berndsen Christopher E.⁵^ORCID,Wright Nathan T.⁵,Jonathan Lederer W.³^ORCID,Kontrogianni-Konstantopoulos Aikaterini¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.

2. Division of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, USA.

3. Department of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

4. Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.

Abstract

The goal of this study is to understand how a particular mutation in obscurin proteins leads to congenital heart disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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