Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

Author:

Ke Jiyuan12,Ma Honglei12,Gu Xin2,Thelen Adam2,Brunzelle Joseph S.3,Li Jiayang4,Xu H. Eric12,Melcher Karsten12

Affiliation:

1. Key Laboratory of Receptor Research, VARI-SIMM Center, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China.

2. Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

3. Department of Molecular Pharmacology and Biological Chemistry, Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA.

4. State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China.

Abstract

Groucho-related corepressors in plants bind a peptide motif found in numerous repressors through a novel peptide recognition fold.

Funder

National Institutes of Health

Van Andel Research Institute

Chinese Ministery of Science and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.

1. Why so repressed? Turning off transcription during plant growth and development;Krogan N. T.;Curr. Opin. Plant Biol.,2009

2. The TOPLESS interactome: A framework for gene repression in Arabidopsis;Causier B.;Plant Physiol.,2012

3. The ’Marx’ of Groucho on development and disease;Buscarlet M.;Trends Cell Biol.,2007

4. Transcriptional repression by Tup1–Ssn6;Malavé T. M.;Biochem. Cell Biol.,2006

5. Groucho/Tup1 family co-repressors in plant development;Liu Z.;Trends Plant Sci.,2008

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