Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia-Reference-Cited by-同舟云学术

Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia

Published:1997-02-28 Issue:5304 Volume:275 Page:1318-1320
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Fan¹,Endo Shogo²,Cleary Leonard J.¹,Eskin Arnold²,Byrne John H.¹

Affiliation:

1. F. Zhang, L. J. Cleary, J. H. Byrne, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA.

2. S. Endo and A. Eskin, Department of Biochemical and Biophysical Sciences, University of Houston, Houston, TX 77204, USA.

Abstract

The role of transforming growth factor-β (TGF-β) in long-term synaptic facilitation was examined in isolated Aplysia ganglia. Treatment with TGF-β1 induced long-term facilitation (24 and 48 hours), but not short-term (5 to 15 minutes) or intermediate-term (2 to 4 hours) facilitation. The long-term effects of TGF-β1 were not additive with those of serotonin. Moreover, serotonin-induced facilitation was blocked by an inhibitor of TGF-β. Thus, activation of TGF-β may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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