Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart-Reference-Cited by-同舟云学术

Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart

Published:1999-03-26 Issue:5410 Volume:283 Page:2080-2082
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Brown Christopher B.¹,Boyer Angelique S.²,Runyan Raymond B.²,Barnett Joey V.³

Affiliation:

1. Department of Pharmacology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232–6600, USA.

2. Department of Cell Biology and Anatomy, University Heart Center, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, USA.

3. Departments of Medicine (Division of Cardiovascular Medicine) and Pharmacology, Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232–6300, USA.

Abstract

Transforming growth factor–β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial cells conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. A. B. Roberts and M. B. Sporn in Peptide Growth Factors and their Receptors M. B. Sporn and A. B. Roberts Eds. (Springer-Verlag New York 1990) vol. 1 pp. 419–472.

2. Mechanism of activation of the TGF-β receptor

3. A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

4. SMADs: mediators and regulators of TGF-β signaling

5. Betaglycan presents ligand to the TGFβ signaling receptor

Cited by 344 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quest for a genetic biomarker for sickle cell disease priapism: rationale, progress and implications;Nature Reviews Urology;2024-08-27

2. Pathophysiology in Brain Arteriovenous Malformations: Focus on Endothelial Dysfunctions and Endothelial-to-Mesenchymal Transition;Biomedicines;2024-08-07

3. The Role of TGFBR3 in the Development of Lung Cancer;Protein & Peptide Letters;2024-07

4. Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM2.5-aggravated COPD airway remodeling by enhancing myofibroblast differentiation;Science China Life Sciences;2024-02-07

5. The Research Progress in Transforming Growth Factor-β2;Cells;2023-11-30