Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

Author:

Saito Hisashi12345,Kanamori Yutaka12345,Takemori Toshitada12345,Nariuchi Hideo12345,Kubota Eiro12345,Takahashi-Iwanaga Hiromi12345,Iwanaga Toshihiko12345,Ishikawa Hiromichi12345

Affiliation:

1. H. Saito, Y. Kanamori, H. Ishikawa, Department of Microbiology, Keio University School of Medicine, Tokyo 160, Japan.

2. T. Takemori, Department of Immunology, National Institute of Infectious Diseases, Tokyo 162, Japan.

3. H. Nariuchi, Department of Allergology, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan.

4. E. Kubota, Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa 238, Japan.

5. H. Takahashi-Iwanaga, Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060, Japan.

Abstract

Cryptopatches (CPs) are part of the murine intestinal immune compartment. Cells isolated from CPs of the small intestine that were c-kit positive (c-kit + ) but lineage markers negative (Lin ) gave rise to T cell receptor (TCR) αβ and TCR γδ intestinal intraepithelial T cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, cells from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit + Lin cells, failed to do so. These findings and results of electron microscopic analysis provide evidence of a local intestinal T cell precursor that develops in the CPs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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