Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells-Reference-Cited by-同舟云学术

Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells

Published:2017-05-05 Issue:6337 Volume:356 Page:503-508
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Takahashi Yuta¹²^ORCID,Wu Jun¹³,Suzuki Keiichiro¹^ORCID,Martinez-Redondo Paloma¹^ORCID,Li Mo¹⁴^ORCID,Liao Hsin-Kai¹,Wu Min-Zu¹³,Hernández-Benítez Reyna¹⁴^ORCID,Hishida Tomoaki¹,Shokhirev Maxim Nikolaievich⁵,Esteban Concepcion Rodriguez¹,Sancho-Martinez Ignacio¹^ORCID,Belmonte Juan Carlos Izpisua¹^ORCID

Affiliation:

1. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan.

3. Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, N° 135 Guadalupe 30107, Murcia, Spain.

4. King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

5. Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Stable epigenetic modifications can be introduced into stem cells via precise and targeted manipulation of DNA methylation.

Funder

G Harold and Leila Y. Mathers Foundation

Leona M. and Harry B. Helmsley Charitable Trust

UCAM

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Human DNA methylomes at base resolution show widespread epigenomic differences

2. Global Epigenomic Reconfiguration During Mammalian Brain Development

3. Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells

4. DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

5. The DNA methylation landscape of human early embryos

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