MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility-Reference-Cited by-同舟云学术

MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility

Published:2009-05-15 Issue:5929 Volume:324 Page:938-941
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fan Heng-Yu¹,Liu Zhilin¹,Shimada Masayuki²,Sterneck Esta³,Johnson Peter F.⁴,Hedrick Stephen M.⁵,Richards JoAnne S.¹

Affiliation:

1. Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

2. Department of Applied Animal Science, Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 739-8528, Japan.

3. Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute–Frederick, Frederick, MD 21702–1201, USA.

4. Basic Research Laboratory, Center for Cancer Research, National Cancer Institute–Frederick, Frederick, MD 21702–1201, USA.

5. Molecular Biology Section, Division of Biological, Sciences and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Regulating Oocyte Maturation Understanding exactly how ovarian follicles mature to generate fertile eggs is key to many aspects of fertility treatment. When the pituitary surge of luteinizing hormone (LH) binds to its receptor on granulosa cells of preovulatory follicles, a cascade of signaling events triggers granulosa cells to become luteal cells and the oocyte to resume meiosis. Fan et al. (p. 938 ; see the Perspective by

Duggavathi and Murphy

), using the mouse as a model system, targeted disruption of the kinases ERK1 and ERK2 selectively in granulosa cells. The kinases were essential in vivo mediators of LH induction of ovulation and luteinization.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A

2. Intercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation

3. EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle

4. Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation

5. Paracrine and Autocrine Regulation of Epidermal Growth Factor-Like Factors in Cumulus Oocyte Complexes and Granulosa Cells: Key Roles for Prostaglandin Synthase 2 and Progesterone Receptor

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