Structure of an Agonist-Bound Human A 2A Adenosine Receptor-Reference-Cited by-同舟云学术

Structure of an Agonist-Bound Human A 2A Adenosine Receptor

Published:2011-04-15 Issue:6027 Volume:332 Page:322-327
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xu Fei¹,Wu Huixian¹,Katritch Vsevolod²,Han Gye Won¹,Jacobson Kenneth A.³,Gao Zhan-Guo³,Cherezov Vadim¹,Stevens Raymond C.¹

Affiliation:

1. Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Skaggs School of Pharmacy and Pharmaceutical Sciences and San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA.

3. Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.

Abstract

Changes associated with conformationally selective agonist binding shed light on G protein–coupled receptor activation.

Funder

Protein Structure Initiative

NIH Roadmap Initiative

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

http://www.sciencemag.org/content/332/6027/322.full.pdf

Reference37 articles.

1. High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

2. Structure of a nanobody-stabilized active state of the β2 adrenoceptor

3. Crystal structure of the human β2 adrenergic G-protein-coupled receptor

4. GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function

5. Structure and function of an irreversible agonist-β2 adrenoceptor complex

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