The proteasome controls ESCRT-III–mediated cell division in an archaeon-Reference-Cited by-同舟云学术

The proteasome controls ESCRT-III–mediated cell division in an archaeon

Published:2020-08-07 Issue:6504 Volume:369 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tarrason Risa Gabriel¹^ORCID,Hurtig Fredrik²^ORCID,Bray Sian³^ORCID,Hafner Anne E.¹⁴⁵^ORCID,Harker-Kirschneck Lena¹⁴⁵^ORCID,Faull Peter⁶^ORCID,Davis Colin⁶^ORCID,Papatziamou Dimitra⁷^ORCID,Mutavchiev Delyan R.¹^ORCID,Fan Catherine¹^ORCID,Meneguello Leticia¹^ORCID,Arashiro Pulschen Andre¹^ORCID,Dey Gautam¹^ORCID,Culley Siân¹^ORCID,Kilkenny Mairi³^ORCID,Souza Diorge P.¹^ORCID,Pellegrini Luca³^ORCID,de Bruin Robertus A. M.¹^ORCID,Henriques Ricardo¹^ORCID,Snijders Ambrosius P.⁶^ORCID,Šarić Anđela¹⁴⁵^ORCID,Lindås Ann-Christin²^ORCID,Robinson Nicholas P.⁷^ORCID,Baum Buzz¹⁴^ORCID

Affiliation:

1. MRC-Laboratory for Molecular Cell Biology, University College London (UCL), London, UK.

2. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

3. Biochemistry Department, University of Cambridge, Cambridge, UK.

4. Institute for the Physics of Living Systems, UCL, London, UK.

5. Department of Physics and Astronomy, UCL, London, UK.

6. Proteomics Platform, The Francis Crick Institute, London, UK.

7. Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster, UK.

Abstract

Proteasomal control of division in Archaea In eukaryotes, proteasome-mediated degradation of cell cycle factors triggers mitotic exit, DNA segregation, and cytokinesis, a process that culminates in abscission dependent on the protein ESCRT-III. By studying cell division in an archaeal relative of eukaryotes, Tarrason Risa et al. identified a role for the proteasome in triggering cytokinesis by an archaeal ESCRT-III homolog. Cell division in this archaeon was driven by stepwise remodeling of a composite ESCRT-III–based division ring, where rapid proteasome-mediated degradation of one ESCRT-III subunit triggered the constriction of the remaining ESCRT-III–based copolymer. These data strengthen the case for the eukaryotic cell division machinery having its origins in Archaea. Science , this issue p. eaaz2532

Funder

Wellcome

Francis Crick Institute

Medical Research Council

Cancer Research UK

Human Frontier Science Program

Vetenskapsrådet

BBSRC

MRC

BBSRC Doctoral Training Grant

Publisher

American Association for the Advancement of Science (AAAS)