Draft Genome Sequence of the Sexually Transmitted Pathogen
Trichomonas vaginalis
Author:
Carlton Jane M.12345, Hirt Robert P.12345, Silva Joana C.12345, Delcher Arthur L.12345, Schatz Michael12345, Zhao Qi12345, Wortman Jennifer R.12345, Bidwell Shelby L.12345, Alsmark U. Cecilia M.12345, Besteiro Sébastien12345, Sicheritz-Ponten Thomas12345, Noel Christophe J.12345, Dacks Joel B.12345, Foster Peter G.12345, Simillion Cedric12345, Van de Peer Yves12345, Miranda-Saavedra Diego12345, Barton Geoffrey J.12345, Westrop Gareth D.12345, Müller Sylke12345, Dessi Daniele12345, Fiori Pier Luigi12345, Ren Qinghu12345, Paulsen Ian12345, Zhang Hanbang12345, Bastida-Corcuera Felix D.12345, Simoes-Barbosa Augusto12345, Brown Mark T.12345, Hayes Richard D.12345, Mukherjee Mandira12345, Okumura Cheryl Y.12345, Schneider Rachel12345, Smith Alias J.12345, Vanacova Stepanka12345, Villalvazo Maria12345, Haas Brian J.12345, Pertea Mihaela12345, Feldblyum Tamara V.12345, Utterback Terry R.12345, Shu Chung-Li12345, Osoegawa Kazutoyo12345, de Jong Pieter J.12345, Hrdy Ivan12345, Horvathova Lenka12345, Zubacova Zuzana12345, Dolezal Pavel12345, Malik Shehre-Banoo12345, Logsdon John M.12345, Henze Katrin12345, Gupta Arti12345, Wang Ching C.12345, Dunne Rebecca L.12345, Upcroft Jacqueline A.12345, Upcroft Peter12345, White Owen12345, Salzberg Steven L.12345, Tang Petrus12345, Chiu Cheng-Hsun12345, Lee Ying-Shiung12345, Embley T. Martin12345, Coombs Graham H.12345, Mottram Jeremy C.12345, Tachezy Jan12345, Fraser-Liggett Claire M.12345, Johnson Patricia J.12345
Affiliation:
1. Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA. 2. Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. 3. Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA. 4. Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK. 5. Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Abstract
We describe the genome sequence of the protist
Trichomonas vaginalis
, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference43 articles.
1. Global Prevalence and Incidence of Selected Curable Sexually Transmitted Infections (World Health Organization Geneva 2001) www.who.int/docstore/hiv/GRSTI/006.htm. 2. The New Higher Level Classification of Eukaryotes with Emphasis on the Taxonomy of Protists 3. Eukaryotic evolution, changes and challenges 4. Materials and methods are available as supporting material on Science Online. 5. Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis
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