Affiliation:
1. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Abstract
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in
Drosophila melanogaster
was performed. The mutant line
methuselah
(
mth
) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The
mth
gene predicted a protein with homology to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
Publisher
American Association for the Advancement of Science (AAAS)
Reference44 articles.
1. Rose M. R., Charlesworth B., Nature 287, 141 (1980);
2. ; Genetics 97 173 (1981); ibid. p. 187.
3. Friedman D. B., Johnson T. E., Genetics 118, 75 (1988);
4. Hekimi S., Boutis P., Lakowski B., ibid. 141, 1351 (1995);
5. A C. elegans mutant that lives twice as long as wild type
Cited by
712 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献