Affiliation:
1. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Abstract
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in
Drosophila melanogaster
was performed. The mutant line
methuselah
(
mth
) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The
mth
gene predicted a protein with homology to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
Publisher
American Association for the Advancement of Science (AAAS)
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