Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6C hi Inflammatory Monocytes-Reference-Cited by-同舟云学术

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6C hi Inflammatory Monocytes

Published:2013-09-27 Issue:6153 Volume:341 Page:1483-1488
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nguyen Khoa D.¹²,Fentress Sarah J.³,Qiu Yifu¹,Yun Karen¹,Cox Jeffery S.³,Chawla Ajay¹⁴

Affiliation:

1. Cardiovascular Research Institute, University of California, San Francisco, CA 94158–9001, USA.

2. Immunology Program, Stanford University, Stanford, CA 94305, USA.

3. Department of Microbiology and Immunology, University of California, San Francisco, CA 94158–9001, USA.

4. Department of Physiology and Department of Medicine, University of California, San Francisco, CA 94158–9001, USA.

Abstract

Diurnal Immunology Like most organ systems in the body, several components of the immune system appear to be regulated in a diurnal manner. However, the cell populations affected, the underlying molecular mechanisms controlling these processes, and the functional consequences of such regulation are poorly understood. Now, Nguyen et al. (p. 1483 , published online 22 August; see the Perspective by Druzd and Scheiermann ) have found that trafficking of monocytes to sites of inflammation is regulated in a diurnal manner in mice. Mice harboring a myeloid cell-specific deletion in the clock protein, BMAL1, showed reduced fitness in response to both acute and chronic inflammation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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