Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals-Reference-Cited by-同舟云学术

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

Published:2016-01-22 Issue:6271 Volume:351 Page:391-396
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sharma Upasna¹,Conine Colin C.¹,Shea Jeremy M.¹,Boskovic Ana¹,Derr Alan G.²³,Bing Xin Y.¹,Belleannee Clemence⁴,Kucukural Alper²³,Serra Ryan W.¹,Sun Fengyun¹,Song Lina¹,Carone Benjamin R.¹,Ricci Emiliano P.⁵,Li Xin Z.¹⁵,Fauquier Lucas¹,Moore Melissa J.¹⁵⁶,Sullivan Robert⁴,Mello Craig C.²⁵⁶,Garber Manuel²³,Rando Oliver J.¹

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

2. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

3. Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

4. Department of Obstetrics, Gynecology and Reproduction, Université Laval, Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec G1V 4G2, Canada.

5. RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.

6. Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract

Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm. Chen et al. injected sperm transfer RNA (tRNA) fragments from males that had been kept on a high-fat diet into normal oocytes. The progeny displayed metabolic disorders and concomitant alteration of genes in metabolic pathways. Sharma et al. observed the biogenesis and function of small tRNA-derived fragments during sperm maturation. Further understanding of the mechanisms by which progeny are affected by parental exposure may affect human diseases such as diet-induced metabolic disorders. Science , this issue p. 397 , p. 391

Funder

NIH

March of Dimes

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

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3. Understanding transgenerational epigenetic inheritance via the gametes in mammals

4. Daddy Issues: Paternal Effects on Phenotype

5. Transgenerational Epigenetic Inheritance: Myths and Mechanisms

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