The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling-Reference-Cited by-同舟云学术

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

Published:2011-06-10 Issue:6035 Volume:332 Page:1317-1322
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hsu Peggy P.¹²,Kang Seong A.¹,Rameseder Jonathan³⁴,Zhang Yi⁵⁶,Ottina Kathleen A.¹⁷,Lim Daniel⁴,Peterson Timothy R.¹²,Choi Yongmun⁵⁸,Gray Nathanael S.⁵⁸,Yaffe Michael B.²⁴,Marto Jarrod A.⁵⁶⁸,Sabatini David M.¹²⁴⁷

Affiliation:

1. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

2. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

3. Computational and Systems Biology Initiative, MIT, Cambridge, MA 02139, USA.

4. David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

5. Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), 250 Longwood Avenue, Boston, MA 02115, USA.

6. Blais Proteomics Center, DFCI, 250 Longwood Avenue, Boston, MA 02115, USA.

7. Howard Hughes Medical Institute, MIT, Cambridge, MA 02139,USA.

8. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA.

Abstract

A search for substrates of a growth-promoting kinase revealed a regulatory feedback loop involved in tumor suppression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

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4. Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents

5. An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

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