Attenuation of Virulence by Disruption of the Mycobacterium tuberculosis erp Gene-Reference-Cited by-同舟云学术

Attenuation of Virulence by Disruption of the Mycobacterium tuberculosis erp Gene

Published:1998-10-23 Issue:5389 Volume:282 Page:759-762
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Berthet François-Xavier¹,Lagranderie Micheline¹,Gounon Pierre¹,Laurent-Winter Christine¹,Ensergueix Danielle¹,Chavarot Pierre¹,Thouron Françoise¹,Maranghi Eddie¹,Pelicic Vladimir¹,Portnoı̈ Denis¹,Marchal Gilles¹,Gicquel Brigitte¹

Affiliation:

1. F.-X. Berthet, D. Ensergueix, V. Pelicic, D. Portnoı̈, Unité de Génétique Mycobactérienne, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cédex 15, France. M. Lagranderie and F. Thouron, Laboratoire du BCG, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cédex 15, France. P. Gounon, Station Centrale de Microscopie Electronique, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cédex 15, France. C. Laurent-Winter, Laboratoire d'Electrophorèse Bidimensionnelle, Institut...

Abstract

The virulence of the mycobacteria that cause tuberculosis depends on their ability to multiply in mammalian hosts. Disruption of the bacterial erp gene, which encodes the exported repetitive protein, impaired multiplication of M. tuberculosis and M. bovis Bacille Calmette-Guérin in cultured macrophages and mice. Reintroduction of erp into the mutants restored their ability to multiply. These results indicate that erp contributes to the virulence of M. tuberculosis .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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