Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas-Reference-Cited by-同舟云学术

Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas

Published:1996-12-20 Issue:5295 Volume:274 Page:2057-2059
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Deng Guoren¹,Lu You¹,Zlotnikov Galina¹,Thor Ann D.²,Smith Helene S.³

Affiliation:

1. G. Deng, Y. Lu, G. Zlotnikov, Geraldine Brush Cancer Research Institute, California Pacific Medical Center, 2330 Clay Street, San Francisco, CA 94619, USA.

2. A. D. Thor, Department of Pathology, Northwestern University School of Medicine, Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201, USA.

3. H. S. Smith, Geraldine Brush Cancer Research Institute, California Pacific Medical Center, 2330 Clay Street, San Francisco, CA 94619, and Department of Medicine, University of California, San Francisco, CA 94143, USA.

Abstract

Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent aberration was at chromosome 3p22-25; of ten cases with this LOH in the carcinoma, six displayed the same LOH in adjacent normal lobules. This suggests that in a subset of sporadic breast cancers, a tumor suppresser gene at 3p22-25 may be important in initiation or early progression of tumorigenesis. Among sixteen breast cancers with LOH at 17p13.1 and five breast cancers with LOH at 11p15.5, one case each displayed the same LOH in adjacent normal lobules. Thus the molecular heterogeneity that characterizes invasive breast cancers may occur at the earliest detectable stages of progression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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