Chemical Etiology of Nucleic Acid Structure

Author:

Eschenmoser Albert1

Affiliation:

1. The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, and Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule (ETH), Universitätstrasse 16, CH-8092 Zürich, Switzerland.

Abstract

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference118 articles.

1. A. Einstein in Festschrift für Aurel Stodola E. Honegger Ed. (Orell Füssli Verlag Zürich 1929) p. 126.

2. Etiology is the science of causes or origins ( Webster's New 20th Century Dictionary of the English Language Unabridged ed. 2 s.v. “etiology”).

3. RNA not DNA is to serve as a reference structure for choosing alternatives because biological as well as chemical reasoning indicates that RNA preceded DNA in biological evolution [see for example G. F. Joyce and L. E. Orgel in The RNA World R. F. Gesteland T. R. Cech J. F. Atkins Eds. (Cold Spring Harbor Laboratory Press Plainview NY ed. 2 1999) p. 49].

4. For an alternative view see for example S. A. Kauffman The Origins of Order: Self-Organization and Selection in Evolution (Oxford Univ. Press Oxford 1993).

5. Eigen M., Naturwissenschaften 58, 465 (1971);

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