Minimal functional driver gene heterogeneity among untreated metastases-Reference-Cited by-同舟云学术

Minimal functional driver gene heterogeneity among untreated metastases

Published:2018-09-07 Issue:6406 Volume:361 Page:1033-1037
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Reiter Johannes G.¹²^ORCID,Makohon-Moore Alvin P.³,Gerold Jeffrey M.²^ORCID,Heyde Alexander²^ORCID,Attiyeh Marc A.³^ORCID,Kohutek Zachary A.⁴^ORCID,Tokheim Collin J.⁵^ORCID,Brown Alexia³^ORCID,DeBlasio Rayne M.³^ORCID,Niyazov Juliana³,Zucker Amanda³^ORCID,Karchin Rachel⁵⁶^ORCID,Kinzler Kenneth W.⁷⁸⁹^ORCID,Iacobuzio-Donahue Christine A.³¹⁰^ORCID,Vogelstein Bert⁷⁸⁹¹¹^ORCID,Nowak Martin A.²¹²^ORCID

Affiliation:

1. Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

2. Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA.

3. The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

4. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.

6. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

7. The Ludwig Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

8. The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

9. Sidney Kimmel Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

10. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

11. Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

12. Department of Organismic and Evolutionary Biology and Department of Mathematics, Harvard University, Cambridge, MA 02138, USA.

Abstract

Metastatic drivers same as primary Treatment decisions for cancer patients are increasingly guided by analysis of the gene mutations that drive primary tumor growth. Relatively little is known about driver gene mutations in metastases, which cause most cancer-related deaths. Reiter et al. explored whether the growth of different metastatic lesions within an individual patient is fueled by the same or distinct gene mutations. In a study of 76 untreated metastases from 20 patients with different types of cancer, all metastases within a patient shared the same functional driver gene mutations. Thus, analysis of a single biopsy could help oncologists select the optimal therapy for patients with widespread metastatic disease. Science , this issue p. 1033

Funder

National Institutes of Health

Office of Naval Research

Lustgarten Foundation

Virginia and D.K. Ludwig Fund for Cancer Research

The Sol Goldman Center for Pancreatic Cancer Research

Landry Cancer Biology Fellowship

Austrian Science Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary