Affiliation:
1. Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Abstract
Silicon Siting
The synthesis of many pharmaceutical and agrochemical compounds requires selective functionalization of multiple different sites on aromatic ring frameworks. The size and electronic properties of the first substituent added can influence where the next one is likely to end up.
Cheng and Hartwig
(p.
853
, see the Perspective by
Tobisu and Chatani
) discovered a rhodium-catalyzed reaction that is particularly sensitive to size that places a silicon substituent as far away as possible from the largest group already on the ring. The silicon group can then be replaced with carbon, oxygen, nitrogen, or halide substituents as needed.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
418 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献