The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation-Reference-Cited by-同舟云学术

The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation

Published:2011-08-05 Issue:6043 Volume:333 Page:765-769
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wang Lan¹,Gural Alexander¹,Sun Xiao-Jian²,Zhao Xinyang¹,Perna Fabiana¹,Huang Gang¹,Hatlen Megan A.¹,Vu Ly¹,Liu Fan¹,Xu Haiming¹,Asai Takashi¹,Xu Hao¹,Deblasio Tony¹,Menendez Silvia¹,Voza Francesca¹,Jiang Yanwen³,Cole Philip A.⁴,Zhang Jinsong⁵,Melnick Ari³,Roeder Robert G.²,Nimer Stephen D.¹

Affiliation:

1. Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

2. Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

3. Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

4. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5. Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA.

Abstract

A protein that drives the growth of leukemia does so only when it carries a specific posttranslational modification.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

2. Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

3. Post-translational modifications of Runx1 regulate its activity in the cell

4. AML1 Is Functionally Regulated through p300-mediated Acetylation on Specific Lysine Residues

5. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

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