ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling-Reference-Cited by-同舟云学术

ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

Published:2016-06-03 Issue:6290 Volume:352 Page:1221-1225
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wright Roni H. G.¹²,Lioutas Antonios¹²,Le Dily Francois¹²,Soronellas Daniel¹²,Pohl Andy¹²,Bonet Jaume²³,Nacht A. S.¹²,Samino Sara⁴⁵,Font-Mateu Jofre¹²,Vicent Guillermo P.¹²,Wierer Michael¹²,Trabado Miriam A.⁶,Schelhorn Constanze⁷,Carolis Carlo⁶,Macias Maria J.⁷⁸,Yanes Oscar⁴⁵,Oliva Baldo²³,Beato Miguel¹²

Affiliation:

1. Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology, Barcelona E-09003, Spain.

2. Universitat Pompeu Fabra, Barcelona E-08003, Spain.

3. Structural Bioinformatics Laboratory, Universitat Pompeu Fabra, Barcelona E-08003, Spain.

4. Metabolomics Platform, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28029 Madrid, Spain.

5. Center for Omic Sciences and Department of Electronic Engineering, Rovira i Virgili University, 43007 Tarragona, Spain.

6. Biomolecular Screening and Protein Technologies Unit, Centre de Regulació Genòmica, Barcelona E-08003, Spain.

7. Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona 08028, Spain.

8. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.

Abstract

A nuclear power source in the cell DNA is packaged onto nucleosomes, the principal component of chromatin. This chromatin must be remodeled to allow gene transcription, DNA replication, and DNA repair machineries access to the enclosed DNA. Chromatin-remodeling complexes require high levels of cellular energy to do their job. Wright et al. show that the energy needed to remodel chromatin can be derived from a source, poly-ADP-ribose, in the cell nucleus, rather than by diffusion of ATP from mitochondria in the cytoplasm, the usual powerhouse of the cell. Poly-ADP-ribose is converted to ADP-ribose and then to ATP, which can be used to fuel chromatin remodeling within the nucleus. Science , this issue p. 1221

Funder

Spanish MEC

Catalan government (AGAUR)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

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