Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom-Reference-Cited by-同舟云学术

Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom

Published:2018-09-28 Issue:6409 Volume:361 Page:1356-1358
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Brunson John K.¹²^ORCID,McKinnie Shaun M. K.¹^ORCID,Chekan Jonathan R.¹^ORCID,McCrow John P.²,Miles Zachary D.¹,Bertrand Erin M.²³^ORCID,Bielinski Vincent A.⁴^ORCID,Luhavaya Hanna¹,Oborník Miroslav⁵,Smith G. Jason⁶^ORCID,Hutchins David A.⁷^ORCID,Allen Andrew E.²⁸^ORCID,Moore Bradley S.¹⁹^ORCID

Affiliation:

1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA.

2. Microbial and Environmental Genomics Group, J. Craig Venter Institute, La Jolla, CA 92037, USA.

3. Department of Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.

4. Synthetic Biology and Bioenergy Group, J. Craig Venter Institute, La Jolla, CA 92037, USA.

5. Institute of Parasitology, University of South Bohemia and Biology Center CAS, Branišovská 31, 370 05 České Budějovice, Czech Republic.

6. Moss Landing Marine Laboratories, 8272 Moss Landing Road, Moss Landing, CA 95039, USA.

7. Marine and Environmental Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.

8. Integrative Oceanography Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92037, USA.

9. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

How algae turn tides toxic Algal blooms can devastate marine mammal communities through the production of neurotoxins that accumulate within the food web. Brunson et al. identified a cluster of genes associated with biosynthesis of the neurotoxin domoic acid in a marine diatom (see the Perspective by Pohnert et al. ). In vitro experiments established a series of enzymes that create the core structure of the toxin. Knowledge of the genes involved in domoic acid production will allow for genetic monitoring of algal blooms and aid in identifying conditions that trigger toxin production. Science , this issue p. 1356 ; see also p. 1308

Funder

National Science Foundation

National Institutes of Health

Czech Science Foundation

U.S. Department of Energy

Gordon and Betty Moore Foundation

National Institute of Environmental Health Sciences

Dickinson-McCrink Fellowship

Natural Sciences and Engineering Research Council of Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject