Ancient chicken remains reveal the origins of virulence in Marek’s disease virus-Reference-Cited by-同舟云学术

Ancient chicken remains reveal the origins of virulence in Marek’s disease virus

Published:2023-12-15 Issue:6676 Volume:382 Page:1276-1281
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fiddaman Steven R.¹^ORCID,Dimopoulos Evangelos A.²³^ORCID,Lebrasseur Ophélie⁴⁵^ORCID,du Plessis Louis⁶⁷^ORCID,Vrancken Bram⁸⁹^ORCID,Charlton Sophy²¹⁰^ORCID,Haruda Ashleigh F.²^ORCID,Tabbada Kristina²,Flammer Patrik G.¹,Dascalu Stefan¹^ORCID,Marković Nemanja¹¹^ORCID,Li Hannah¹²^ORCID,Franklin Gabrielle¹³^ORCID,Symmons Robert¹⁴,Baron Henriette¹⁵^ORCID,Daróczi-Szabó László¹⁶^ORCID,Shaymuratova Dilyara N.¹⁷^ORCID,Askeyev Igor V.¹⁷^ORCID,Putelat Olivier¹⁸^ORCID,Sana Maria¹⁹^ORCID,Davoudi Hossein²⁰^ORCID,Fathi Homa²⁰^ORCID,Mucheshi Amir Saed²¹^ORCID,Vahdati Ali Akbar²²^ORCID,Zhang Liangren²³^ORCID,Foster Alison²⁴,Sykes Naomi²⁵^ORCID,Baumberg Gabrielle Cass²^ORCID,Bulatović Jelena²⁶^ORCID,Askeyev Arthur O.¹⁷^ORCID,Askeyev Oleg V.¹⁷^ORCID,Mashkour Marjan²⁰²⁷,Pybus Oliver G.¹²⁸^ORCID,Nair Venugopal¹²⁹^ORCID,Larson Greger²^ORCID,Smith Adrian L.¹^ORCID,Frantz Laurent A. F.³⁰³¹^ORCID

Affiliation:

1. Department of Biology, University of Oxford, Oxford, UK.

2. The Palaeogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.

3. Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

4. Centre d’Anthropobiologie et de Génomique de Toulouse, CNRS/Université Toulouse III Paul Sabatier, Toulouse, France.

5. Instituto Nacional de Antropología y Pensamiento Latinoamericano, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

6. Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

7. Swiss Institute of Bioinformatics, Lausanne, Switzerland.

8. Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.

9. Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium.

10. BioArCh, Department of Archaeology, University of York, York, UK.

11. Institute of Archaeology, Belgrade, Serbia.

12. Institute of Immunity and Transplantation, University College London, London, UK.

13. Silkie Club of Great Britain, Charing, UK.

14. Fishbourne Roman Palace, Fishbourne, UK.

15. Leibniz-Zentrum für Archäologie, Mainz, Germany.

16. Medieval Department, Budapest History Museum, Budapest, Hungary.

17. Laboratory of Biomonitoring, The Institute of Problems in Ecology and Mineral Wealth, Tatarstan Academy of Sciences, Kazan, Russia.

18. Archéologie Alsace–PAIR, Sélestat, Bas-Rhin, France.

19. Departament de Prehistòria, Universitat Autònoma de Barcelona, Barcelona, Spain.

20. Bioarchaeology Laboratory, Central Laboratory, University of Tehran, Tehran, Iran.

21. Department of Art and Architecture, Payame Noor University (PNU), Tehran, Iran.

22. Iranian Ministry of Cultural Heritage, Tourism, and Handicrafts, North Khorasan Office, Iran.

23. Department of Archaeology, School of History, Nanjing University, China.

24. Headland Archaeology, Edinburgh, UK.

25. Department of Archaeology, University of Exeter, Exeter, UK.

26. Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden.

27. CNRS, National Museum Natural History Paris, Paris, France.

28. Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK.

29. Viral Oncogenesis Group, Pirbright Institute, Woking, UK.

30. Palaeogenomics Group, Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, Ludwig-Maximilians-Universitat, Munich, Germany.

31. School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.

Abstract

The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.adg2238

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