Control of meiotic pairing and recombination by chromosomally tethered 26 S proteasome

Author:

Ahuja Jasvinder S.1,Sandhu Rima1,Mainpal Rana2,Lawson Crystal3,Henley Hanna1,Hunt Patricia A.3,Yanowitz Judith L.2,Börner G. Valentin145

Affiliation:

1. Center for Gene Regulation in Health and Disease and Department of Biological, Geological and Environmental Sciences, Cleveland State University (CSU), Cleveland, OH, USA.

2. Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

3. School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA, USA.

4. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.

5. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Abstract

Proteasomes and SUMO wrestle chromosomes Meiosis is the double cell division that generates haploid gametes from diploid parental cells. Pairing of homologous chromosomes during the first meiotic division ensures that each gamete receives a complete set of chromosomes. The proteasome, on the other hand, is a molecular machine that degrades proteins tagged for destruction within the cell (see the Perspective by Zetka). Ahuja et al. show that the proteasome is also involved in ensuring that homologous chromosomes pair with each other during meiosis. Rao et al. show that the SUMO (small ubiquitin-like modifier) protein, ubiquitin, and the proteasome localize to the axes between homologous chromosomes. In this location, they help mediate chromosome pairing and recombination between homologs. Science , this issue p. 349 , p. 408 ; see also p. 403

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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