Affiliation:
1. Department of Molecular Evolution, Evolutionary Biology Center, University of Uppsala, Uppsala, Sweden.
2. Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA.
Abstract
Comparison of two fully sequenced genomes of
Buchnera aphidicola
, the obligate endosymbionts of aphids, reveals the most extreme genome stability to date: no chromosome rearrangements or gene acquisitions have occurred in the past 50 to 70 million years, despite substantial sequence evolution and the inactivation and loss of individual genes. In contrast, the genomes of their closest free-living relatives,
Escherichia coli
and
Salmonella
spp., are more than 2000-fold more labile in content and gene order. The genomic stasis of
B. aphidicola
, likely attributable to the loss of phages, repeated sequences, and
recA
, indicates that
B. aphidicola
is no longer a source of ecological innovation for its hosts.
Publisher
American Association for the Advancement of Science (AAAS)
Reference19 articles.
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