Affiliation:
1. Benjamin O. Anderson is a professor of Surgery and Global Health Medicine at the University of Washington and the Fred Hutchinson Cancer Research Center, Seattle, Washington, and served as chair and director of the Breast Health Global Initiative.
Abstract
Few diseases have seen more rapid scientific progress over the past three decades than breast cancer. Beginning in the 1980s, screening mammography led to sweeping improvements in early cancer detection. At the same time, endocrine treatment and systemic chemotherapy proved life-saving. The development of drugs that target hormone receptor and
HER2/neu
oncogene signaling pathways, coupled with biomarker-based subclassification of the disease, have helped make breast cancer therapy a more precise science. Cloning of the
BRCA
genes provided insight into inherited predisposition and the opportunity for genetic testing. As a result of these advances, breast cancer death rates in the United States dropped by 34% between 1990 and 2014.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
28 articles.
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