Correlated gene expression supports synchronous activity in brain networks

Author:

Richiardi Jonas12,Altmann Andre1,Milazzo Anna-Clare13,Chang Catie4,Chakravarty M. Mallar56,Banaschewski Tobias7,Barker Gareth J.8,Bokde Arun L.W.9,Bromberg Uli10,Büchel Christian10,Conrod Patricia811,Fauth-Bühler Mira12,Flor Herta13,Frouin Vincent14,Gallinat Jürgen15,Garavan Hugh916,Gowland Penny17,Heinz Andreas15,Lemaître Hervé1819,Mann Karl F.12,Martinot Jean-Luc1819,Nees Frauke13,Paus Tomáš2021,Pausova Zdenka22,Rietschel Marcella23,Robbins Trevor W.24,Smolka Michael N.25,Spanagel Rainer26,Ströhle Andreas15,Schumann Gunter827,Hawrylycz Mike28,Poline Jean-Baptiste29,Greicius Michael D.1,Albrecht Lisa,Andrew Chris,Arroyo Mercedes,Artiges Eric,Aydin Semiha,Bach Christine,Banaschewski Tobias,Barbot Alexis,Barker Gareth,Boddaert Nathalie,Bokde Arun,Bricaud Zuleima,Bromberg Uli,Bruehl Ruediger,Büchel Christian,Cachia Arnaud,Cattrell Anna,Conrod Patricia,Constant Patrick,Dalley Jeffrey,Decideur Benjamin,Desrivieres Sylvane,Fadai Tahmine,Flor Herta,Frouin Vincent,Gallinat Jürgen,Garavan Hugh,Briand Fanny Gollier,Gowland Penny,Heinrichs Bert,Heinz Andreas,Heym Nadja,Hübner Thomas,Ireland James,Ittermann Bernd,Jia Tianye,Lathrop Mark,Lanzerath Dirk,Lawrence Claire,Lemaitre Hervé,Lüdemann Katharina,Macare Christine,Mallik Catherine,Mangin Jean-François,Mann Karl,Martinot Jean- Luc,Mennigen Eva,Mesquita de Carvahlo Fabiana,Mignon Xavier,Miranda Ruben,Müller Kathrin,Nees Frauke,Nymberg Charlotte,Paillere Marie-Laure,Paus Tomas,Pausova Zdenka,Poline Jean-Baptiste,Poustka Luise,Rapp Michael,Robert Gabriel,Reuter Jan,Rietschel Marcella,Ripke Stephan,Robbins Trevor,Rodehacke Sarah,Rogers John,Romanowski Alexander,Ruggeri Barbara,Schmäl Christine,Schmidt Dirk,Schneider Sophia,Schumann MarkGunter,Schubert Florian,Schwartz Yannick,Smolka Michael,Sommer Wolfgang,Spanagel Rainer,Speiser Claudia,Spranger Tade,Stedman Alicia,Steiner Sabina,Stephens Dai,Strache Nicole,Ströhle Andreas,Struve Maren,Subramaniam Naresh,Topper Lauren,Whelan Robert,Williams Steve,Yacubian Juliana,Zilbovicius Monica,Wong C Peng,Lubbe Steven,Martinez-Medina Lourdes,Fernandes Alinda,Tahmasebi Amir,

Affiliation:

1. Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

2. Laboratory of Neurology and Imaging of Cognition, Department of Neuroscience, University of Geneva, Geneva, Switzerland.

3. The War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.

4. Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

5. Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.

6. Departments of Psychiatry and Biomedical Engineering, McGill University, Montreal, Canada.

7. Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

8. Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.

9. Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

10. Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.

11. Department of Psychiatry, Université de Montréal, Centre Hospitalier Universitaire (CHU) Ste Justine Hospital, Montréal, Canada.

12. Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

13. Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

14. Neurospin, Commissariat à l’Energie Atomique et aux Energies Alternatives, Paris, France.

15. Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Berlin, Germany.

16. Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.

17. School of Physics and Astronomy, University of Nottingham, Nottingham, UK.

18. Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging and Psychiatry,” University Paris Sud, Orsay, France.

19. INSERM Unit 1000 at Maison de Solenn, Assistance Publique Hôpitaux de Paris (APHP), Cochin Hospital, University Paris Descartes, Sorbonne Paris Cité, Paris, France.

20. Rotman Research Institute, University of Toronto, Toronto, Canada.

21. School of Psychology, University of Nottingham, Nottingham, UK.

22. The Hospital for Sick Children, University of Toronto, Toronto, Canada.

23. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

24. Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, UK.

25. Department of Psychiatry and Psychotherapy, and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.

26. Department of Psychopharmacology, Central Institute of Mental Health, Faculty of Clinical Medicine Mannheim, Mannheim, Germany.

27. Medical Research Council (MRC) Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK.

28. Allen Institute for Brain Science, Seattle, WA, USA.

29. Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.

Abstract

Cooperating brain regions express similar genes When the brain is at rest, a number of distinct areas are functionally connected. They tend to be organized in networks. Richiardi et al. compared brain imaging and gene expression data to build computational models of these networks. These functional networks are underpinned by the correlated expression of a core set of 161 genes. In this set, genes coding for ion channels and other synaptic functions such as neurotransmitter release dominate. Science , this issue p. 1241

Funder

National Institutes of Health

U.S. National Institutes of Health

NIH

Wellcome Trust

DFG

Medical Research Council

National Institute for Health Research

BMBF

Fondation pour la Recherche Médicale

Feldman Family Foundation

Eranet-Neuron

MILDECA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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