Ancestry-inclusive dog genomics challenges popular breed stereotypes-Reference-Cited by-同舟云学术

Ancestry-inclusive dog genomics challenges popular breed stereotypes

Published:2022-04-29 Issue:6592 Volume:376 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Morrill Kathleen¹²³^ORCID,Hekman Jessica³^ORCID,Li Xue¹²³,McClure Jesse¹,Logan Brittney¹³^ORCID,Goodman Linda³⁴^ORCID,Gao Mingshi¹²,Dong Yinan¹³,Alonso Marjie⁵⁶,Carmichael Elena¹³⁷,Snyder-Mackler Noah⁸⁹¹⁰^ORCID,Alonso Jacob³,Noh Hyun Ji³^ORCID,Johnson Jeremy³,Koltookian Michele³,Lieu Charlie³¹¹^ORCID,Megquier Kate³^ORCID,Swofford Ross³^ORCID,Turner-Maier Jason³^ORCID,White Michelle E.¹³^ORCID,Weng Zhiping¹^ORCID,Colubri Andrés¹³^ORCID,Genereux Diane P.³^ORCID,Lord Kathryn A.¹³^ORCID,Karlsson Elinor K.¹²³¹¹¹²^ORCID

Affiliation:

1. Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.

2. Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.

3. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

4. Fauna Bio Inc., Emeryville, CA 94608, USA.

5. The International Association of Animal Behavior Consultants, Cranberry Township, PA 16066, USA.

6. IAABC Foundation, Cranberry Township, PA 16066, USA.

7. Rice University, Houston, TX 77005, USA.

8. Center for Evolution and Medicine, Arizona State University, Tempe, AZ 85251, USA.

9. School for Human Evolution and Social Change, Arizona State University, Tempe, AZ 85251, USA.

10. School of Life Sciences, Arizona State University, Tempe, AZ 85251, USA.

11. Darwin’s Ark Foundation, Seattle, WA 98026, USA.

12. Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.

Abstract

Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h2) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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