Identification and Functional Characterization of Brainstem Cannabinoid CB 2 Receptors-Reference-Cited by-同舟云学术

Identification and Functional Characterization of Brainstem Cannabinoid CB 2 Receptors

Published:2005-10-14 Issue:5746 Volume:310 Page:329-332
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Van Sickle Marja D.¹²³⁴⁵,Duncan Marnie¹²³⁴⁵,Kingsley Philip J.¹²³⁴⁵,Mouihate Abdeslam¹²³⁴⁵,Urbani Paolo¹²³⁴⁵,Mackie Ken¹²³⁴⁵,Stella Nephi¹²³⁴⁵,Makriyannis Alexandros¹²³⁴⁵,Piomelli Daniele¹²³⁴⁵,Davison Joseph S.¹²³⁴⁵,Marnett Lawrence J.¹²³⁴⁵,Di Marzo Vincenzo¹²³⁴⁵,Pittman Quentin J.¹²³⁴⁵,Patel Kamala D.¹²³⁴⁵,Sharkey Keith A.¹²³⁴⁵

Affiliation:

1. Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1.

2. Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232–0146, USA.

3. Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy.

4. Department of Anesthesiology and Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195–6540, USA.

5. Department of Pharmacology, Psychiatry, and Behavioral Sciences, University of Washington, Seattle, WA 98195–7280, USA.

Abstract

The presence and function of CB 2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB 2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB 2 receptors in the brainstem were activated by a CB 2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB 1 receptors. CB 2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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