Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall-Reference-Cited by-同舟云学术

Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall

Published:1999-07-30 Issue:5428 Volume:285 Page:760-763
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mazmanian Sarkis K.¹,Liu Gwen¹,Ton-That Hung¹,Schneewind Olaf¹

Affiliation:

1. Department of Microbiology and Immunology, UCLA School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

Abstract

Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant defective in the anchoring of surface proteins was isolated and shown to carry a mutation in the srtA gene. Overexpression of srtA increased the rate of surface protein anchoring, and homologs of srtA were found in other pathogenic Gram-positive bacteria. The protein specified by srtA , sortase, may be a useful target for the development of new antimicrobial drugs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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