The Mutational Landscape of Head and Neck Squamous Cell Carcinoma-Reference-Cited by-同舟云学术

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Published:2011-08-26 Issue:6046 Volume:333 Page:1157-1160
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Stransky Nicolas¹,Egloff Ann Marie²,Tward Aaron D.¹³⁴,Kostic Aleksandar D.¹⁵,Cibulskis Kristian¹,Sivachenko Andrey¹,Kryukov Gregory V.¹⁵,Lawrence Michael S.¹,Sougnez Carrie¹,McKenna Aaron¹,Shefler Erica¹,Ramos Alex H.¹,Stojanov Petar¹,Carter Scott L.¹,Voet Douglas¹,Cortés Maria L.¹,Auclair Daniel¹,Berger Michael F.¹,Saksena Gordon¹,Guiducci Candace¹,Onofrio Robert C.¹,Parkin Melissa¹,Romkes Marjorie⁶,Weissfeld Joel L.⁷,Seethala Raja R.⁸,Wang Lin⁸,Rangel-Escareño Claudia⁹,Fernandez-Lopez Juan Carlos⁹,Hidalgo-Miranda Alfredo⁹,Melendez-Zajgla Jorge⁹,Winckler Wendy¹,Ardlie Kristin¹,Gabriel Stacey B.¹,Meyerson Matthew¹⁵¹⁰¹¹,Lander Eric S.¹⁵¹²,Getz Gad¹,Golub Todd R.¹⁵¹¹¹³¹⁴,Garraway Levi A.¹⁵¹⁰¹¹,Grandis Jennifer R.²¹⁵

Affiliation:

1. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

2. Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

3. Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA.

4. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.

5. Harvard Medical School, Boston, MA 02115, USA.

6. Department of Medicine, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA.

7. Department of Epidemiology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.

8. Department of Pathology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

9. Instituto Nacional de Medicina Genómica, Mexico City, 01900, Mexico.

10. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

11. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

12. Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

13. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

14. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

15. Department of Pharmacology and Chemical Biology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

Abstract

The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference66 articles.

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5. The mutation spectrum revealed by paired genome sequences from a lung cancer patient

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