Spatiotemporal structure of cell fate decisions in murine neural crest-Reference-Cited by-同舟云学术

Spatiotemporal structure of cell fate decisions in murine neural crest

Published:2019-06-07 Issue:6444 Volume:364 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Soldatov Ruslan¹^ORCID,Kaucka Marketa²³^ORCID,Kastriti Maria Eleni²³^ORCID,Petersen Julian²³^ORCID,Chontorotzea Tatiana³^ORCID,Englmaier Lukas²^ORCID,Akkuratova Natalia³⁴^ORCID,Yang Yunshi³^ORCID,Häring Martin⁵^ORCID,Dyachuk Viacheslav⁶⁷^ORCID,Bock Christoph⁸⁹¹⁰^ORCID,Farlik Matthias⁸^ORCID,Piacentino Michael L.¹¹^ORCID,Boismoreau Franck¹²,Hilscher Markus M.⁵¹³^ORCID,Yokota Chika¹³,Qian Xiaoyan¹³¹⁴^ORCID,Nilsson Mats¹³,Bronner Marianne E.¹¹^ORCID,Croci Laura¹⁵^ORCID,Hsiao Wen-Yu¹⁶,Guertin David A.¹⁶,Brunet Jean-Francois¹²^ORCID,Consalez Gian Giacomo¹⁵^ORCID,Ernfors Patrik⁵^ORCID,Fried Kaj⁶^ORCID,Kharchenko Peter V.¹¹⁷,Adameyko Igor²³^ORCID

Affiliation:

1. Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.

3. Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.

4. Institute of Translational Biomedicine, St Petersburg University, 199034 St Petersburg, Russia.

5. Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.

6. Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.

7. National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia.

8. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

9. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

10. Max Planck Institute for Informatics, Saarbrücken, Germany.

11. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

12. Institut de Biologie de l’ENS (IBENS), INSERM, CNRS, École Normale Supérieure, PSL Research University, 75005 Paris, France.

13. Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University, 17165 Solna, Sweden.

14. Cartana AB, 17165 Solna, Sweden.

15. San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, 20132, Milan, Italy.

16. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

17. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Abstract

Binary decisions refine fate decisions Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov et al. analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other. Science , this issue p. eaas9536 ; see also p. 937

Funder

NIH Office of the Director

NSF Office of the Director

European Research Council

Knut och Alice Wallenbergs Stiftelse

Vetenskapsrådet

Bertil Hållstens Forskningsstiftelse

paradifference foundation

Familjen Erling Perssons stiftelse

Publisher

American Association for the Advancement of Science (AAAS)

Subject