Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident-Reference-Cited by-同舟云学术

Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident

Published:2021-05-14 Issue:6543 Volume:372 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Morton Lindsay M.¹^ORCID,Karyadi Danielle M.²^ORCID,Stewart Chip³^ORCID,Bogdanova Tetiana I.⁴^ORCID,Dawson Eric T.²⁵^ORCID,Steinberg Mia K.⁶^ORCID,Dai Jieqiong⁶,Hartley Stephen W.²^ORCID,Schonfeld Sara J.¹^ORCID,Sampson Joshua N.⁷,Maruvka Yosef E.³,Kapoor Vidushi⁶,Ramsden Dale A.⁸^ORCID,Carvajal-Garcia Juan⁹^ORCID,Perou Charles M.¹⁰¹¹^ORCID,Parker Joel S.¹¹^ORCID,Krznaric Marko¹²^ORCID,Yeager Meredith⁶^ORCID,Boland Joseph F.⁶,Hutchinson Amy⁶^ORCID,Hicks Belynda D.⁶^ORCID,Dagnall Casey L.⁶^ORCID,Gastier-Foster Julie M.¹³¹⁴^ORCID,Bowen Jay¹³^ORCID,Lee Olivia²^ORCID,Machiela Mitchell J.¹⁵^ORCID,Cahoon Elizabeth K.¹^ORCID,Brenner Alina V.¹⁶^ORCID,Mabuchi Kiyohiko¹^ORCID,Drozdovitch Vladimir¹^ORCID,Masiuk Sergii¹⁷,Chepurny Mykola¹⁷,Zurnadzhy Liudmyla Yu.⁴,Hatch Maureen¹,Berrington de Gonzalez Amy¹^ORCID,Thomas Gerry A.¹²^ORCID,Tronko Mykola D.¹⁸^ORCID,Getz Gad³¹⁹²⁰^ORCID,Chanock Stephen J.²^ORCID

Affiliation:

1. Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

2. Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

3. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

4. Laboratory of Morphology of the Endocrine System, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.

5. Nvidia Corporation, Santa Clara, CA 95051, USA.

6. Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.

7. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

8. Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

9. Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.

10. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

11. Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

12. Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.

13. Nationwide Children’s Hospital, Biospecimen Core Resource, Columbus, OH 43205, USA.

14. Departments of Pathology and Pediatrics, Ohio State University College of Medicine, Columbus, OH 43210, USA.

15. Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

16. Radiation Effects Research Foundation, Hiroshima 732-0815, Japan.

17. Radiological Protection Laboratory, Institute of Radiation Hygiene and Epidemiology, National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine.

18. Department of Fundamental and Applied Problems of Endocrinology, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.

19. Center for Cancer Research and Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

20. Harvard Medical School, Boston, MA 02115, USA.

Abstract

Genomics of radiation-induced damage The potential adverse effects of exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, as well as long-term sequelae such as increased risk of cancer. There have been a few studies examining transgenerational risks of radiation exposure but the results have been inconclusive. Morton et al. analyzed papillary thyroid tumors, normal thyroid tissue, and blood from hundreds of survivors of the Chernobyl nuclear accident and compared them against those of unexposed patients. The findings offer insight into the process of radiation-induced carcinogenesis and characteristic patterns of DNA damage associated with environmental radiation exposure. In a separate study, Yeager et al. analyzed the genomes of 130 children and parents from families in which one or both parents had experienced gonadal radiation exposure related to the Chernobyl accident and the children were conceived between 1987 and 2002. Reassuringly, the authors did not find an increase in new germline mutations in this population. Science , this issue p. eabg2538 , p. 725

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference122 articles.

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